#ifndef ___SIMULATE_CODONS_JUMPS__ #define ___SIMULATE_CODONS_JUMPS__ #include "simulateJumpsAbstract.h" #include "codon.h" using namespace std; /****************************************************************** This class implements simulateJumpsAbstract for small alphabets: (tested so far up to 3) *******************************************************************/ class simulateCodonsJumps:public simulateJumpsAbstract { public: simulateCodonsJumps(const tree& inTree, const stochasticProcess& sp, const int alphabetSize); virtual ~simulateCodonsJumps(); //for a branch length specified by a nodeName: //give the expected number of jumps (changes) from fromId to toId that occured along the specified branh length, //in which the starting character is terminalStart and the terminal character is terminalEnd MDOUBLE getExpectation(const string& nodeName, int terminalStart, int terminalEnd, int fromId, int toId); MDOUBLE getExpectation(const string& nodeName, int terminalStart, int terminalEnd, codonUtility::replacementType substitutionType); //same as above, except here we return the probability of a jump from fromId to toId given //terminal states terminalStart, terminalEnd in this branch MDOUBLE getProb(const string& nodeName, int terminalStart, int terminalEnd, int fromId, int toId); MDOUBLE getProb(const string& nodeName, int terminalStart, int terminalEnd, codonUtility::replacementType substitutionType); private: void init(); void runOneIter(int state); void computeExpectationsAndPosterior(); private: //_node2Jumps: maps a node name (which specify a branch length) to //the expected number of synonymous and nonsynonymous jumps between any two characters along the branch leading from the father to this node //given the terminal characters of this branch. //We use a "combined alphabet" to make access easier. see getCombinedState() for details //The dimension of the vector is the combined terminal state and the pair elements are: synonymous and non-synonymous jumps, respectively. map > > _nodes2JumpsExp; //_node2JumpsProb: maps a node name (which specify a branch length) to //the probability of a synonymous and non-synonymous jump between any two characters along the branch leading from the father to this node //given the terminal characters of this branch. //We use a "combined alphabet" to make access easier. see getCombinedState() for details //The dimension of the vector is the combined terminal state and the pair elements are: synonymous and non-synonymous jumps, respectively map > > _nodes2JumpsProb; }; #endif