#ifndef ___SIMULATE_RATESHIFT_JUMPS__ #define ___SIMULATE_RATESHIFT_JUMPS__ #include "simulateJumpsAbstract.h" #include "mulAlphabet.h" using namespace std; /****************************************************************** This class implements simulateJumpsAbstract for multiplied alphabet used for rate-shift *******************************************************************/ class simulateRateShiftJumps:public simulateJumpsAbstract { public: simulateRateShiftJumps(const tree& inTree, const stochasticProcess& sp, const int alphabetSize); virtual ~simulateRateShiftJumps(); void runSimulation(int iterNum, vector inputNodes); //for a branch length specified by a nodeName: //give the expected number of jumps (changes) from fromId to toId that occured along the specified branh length, //in which the starting character is terminalStart and the terminal character is terminalEnd MDOUBLE getExpectation(const string& nodeName, int terminalStart, int terminalEnd, int fromId, int toId); MDOUBLE getExpectation(const string& nodeName, int terminalStart, int terminalEnd, mulAlphabet::rateShiftType my_rateShiftType); //same as above, except here we return the probability of a jump from fromId to toId given //terminal states terminalStart, terminalEnd in this branch MDOUBLE getProb(const string& nodeName, int terminalStart, int terminalEnd, int fromId, int toId); MDOUBLE getProb(const string& nodeName, int terminalStart, int terminalEnd, mulAlphabet::rateShiftType my_rateShiftType); private: void init(); void init(vector inputNodes); void runOneIter(int state); void computeExpectationsAndPosterior(); private: //_node2Jumps: maps a node name (which specify a branch length) to //the expected number of synonymous and nonsynonymous jumps between any two characters along the branch leading from the father to this node //given the terminal characters of this branch. //We use a "combined alphabet" to make access easier. see getCombinedState() for details //The dimension of the vector is the combined terminal state and the pair elements are: synonymous and non-synonymous jumps, respectively. map > > _nodes2JumpsExp; //_node2JumpsProb: maps a node name (which specify a branch length) to //the probability of a synonymous and non-synonymous jump between any two characters along the branch leading from the father to this node //given the terminal characters of this branch. //We use a "combined alphabet" to make access easier. see getCombinedState() for details //The dimension of the vector is the combined terminal state and the pair elements are: synonymous and non-synonymous jumps, respectively map > > _nodes2JumpsProb; int _baseAlphabetSize; int _numRateCategories; }; #endif